The Galperin Lab

signaling in time and space

The Galperin lab investigates the molecular mechanisms that preserve the specificity and integrity of the Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) signaling pathway. This pathway is crucial for embryonic development and is frequently deregulated in developmental syndromes known as RASopathies, such as Noonan-like syndrome, as well as in various cancers. A main focus of the lab is understanding how scaffold proteins, like Shoc2, regulate and modulate these vital signals.

Methodology and Model Systems:
To gain a detailed, spatiotemporal understanding of these signaling mechanisms, the lab employs a powerful combination of approaches. These include quantitative single-cell microscopy for observing dynamics in real-time, genetic techniques, and biochemical studies. We use both mammalian cells and the zebrafish model organism, which is an excellent tool due to its genetic and developmental similarities to humans. The lab leverages advanced CRISPR-based tools to precisely replicate genetic changes found in human patients, allowing us to accurately study their impact on disease development and pave the way for novel therapeutic strategies.


UKNOW - UK Research Could Pave Way for Noonan-like Syndrome Treatment